First, let us analyze the psycho-spiritual changes in patients with premature ovarian failure and the ensuing manifestations. Fear and anxiety: As ovarian function declines, the endometrium no longer changes periodically, resulting in reduced secretions from atrophied uterine and vaginal epithelial cells, menstrual disorders and even amenorrhea, some patients become fearful and anxious, worrying about losing their feminine characteristics and affecting their married life and family harmony. 2. Depression and paranoia: The decline of ovarian function will also cause psychiatric dysfunction and temporary changes in personality, such as withdrawn, suspicious, sentimental, anxious and sad, etc. Some patients often talk to themselves, are sentimental, depressed and extremely depressed. 3.Loss and irritability: Women transition from the reproductive age to premature ovarian failure and gradually move toward aging. This early arrival of the aging process due to disease may bring pessimism and loss to some women; due to endocrine dysfunction, most women become irritable, agitated and even temperamental. The above psychological changes and performance of patients can be understood. The causes of premature ovarian failure are indeed complex and varied, the pathogenesis of premature ovarian failure cannot be accurately interpreted by the medical profession so far, the pain brought to patients by premature ovarian failure in terms of pathology is indeed unspeakable, and the treatment process of premature ovarian failure is indeed relatively long. But still, pain and sorrow, complaints and self-loathing are meaningless to the development of the disease and your future life. Is premature ovarian failure really irreversible? At least the early studies thought so. It was thought that FSH > 40 IU/L meant that the follicles were missing and could lead to permanent infertility. This conclusion has been challenged in later studies. Studies in recent years have shown that about 50% of patients with premature ovarian failure experience intermittent ovulation, and 5-10% have intermittent menstrual resumption or even spontaneous pregnancy after diagnosis. Some scholars also believe that many of the clinically so-called premature ovarian failure is not really premature ovarian failure, but more or less diminished ovarian function, which can be reversed in some patients; some patients with early or mid-stage premature ovarian failure can also partially reverse and restore ovarian function through comprehensive treatment.