When the lymph nodes are enlarged to 28×16 mm, it means that the lymph nodes have lesions, which may be infectious diseases, such as bacterial infections, viral infections, parasitic infections, fungal infections, or non-infectious diseases, such as autoimmune diseases, hematologic tumors, and solid organ tumors, which manifest as metastasis of lymph nodes. In addition to the characteristics of lymph node size, we should also pay attention to the hardness of the lymph nodes, whether the lymph nodes are more mobile, and whether there are systemic symptoms, such as fever and wasting, and make a comprehensive judgment based on several factors in order to find the cause of lymph node enlargement, and then treat accordingly.