Some patients with heart valve disease (such as long-term atrial fibrillation) or mechanical valve implantation, must take long-term anticoagulant drugs to maintain a certain degree of blood dilution to avoid thromboembolism, daily life should pay attention to the following matters: 1, follow the doctor’s instructions to take medication on time, regular follow-up, blood sampling to understand the coagulation function; 2, combined with other diseases need to take other drugs should be consulted to avoid drug interactions that cause abnormal drug effects (such as aspirin, sulfonamides, metformin, etc.); 3, usually pay attention to avoid collision, use soft brushes to brush teeth, nose, gum bleeding, skin bruising, increased female menstruation, should be promptly consulted.