Syphilis belongs to an infectious disease, syphilis 15 years, may be late syphilis, may also be latent syphilis, whether it can be cured, need to be divided into situations to speak. Due to reasons such as taboo, patients do not go to treatment even if they are not feeling well, they may not know about syphilis for 15 years, due to the long course of the disease, if the diagnosis is advanced syphilis, the treatment time may be extended, patients need to adjust their mindset to promote recovery, but usually cannot reverse the organic damage that occurs in the body; 2, latent syphilis: also known as latent syphilis, patients do not have obvious clinical symptoms. Mainly, the autoimmune system is strong and temporarily inhibits the syphilis spirochete virus, at this time there is still a possibility of cure. Regardless of whether the patient has advanced syphilis or latent syphilis, he or she needs to be actively treated with medications such as benzathine penicillin, procaine aqueous penicillin G, etc. under the guidance of a professional doctor and to be reviewed regularly at the hospital. In addition, patients need to disinfect and isolate themselves well to prevent cross-infection.