Standing up with a headache after sitting for a long time may be caused by cerebral ischemia and hypoxia. Suddenly standing up after sitting for a long time may lead to a transient drop in blood pressure, thus causing insufficient blood perfusion to the brain and cerebral hypoxia. Patients may experience headache, dizziness, nausea, vomiting, blackness in front of the eyes, impaired balance, and ataxia. The above conditions are mostly seen in postural hypotension, which may also be caused by low blood pressure in general. If there is postural hypotension, instruct the patient to move slowly when moving and instruct the patient not to sit for a long time. If the patient’s blood pressure is usually low, he or she can take oral pulse drink if necessary, and at the same time, he or she should take appropriate body exercises to enhance physical fitness and increase vascular elasticity.