It is well established that the milk of hepatitis B mothers and hepatitis B surface antigen-positive mothers with combined hepatitis B virus replication indicators is infectious. In addition, when the infant sucks breast milk, it can also swallow some tissue exudate and blood from the mother’s nipple rupture that may contain hepatitis virus, and some of the virus invades directly through the infant’s abraded mucous membrane, causing infection in the infant. Therefore, the above-mentioned mothers were once considered unsuitable for breastfeeding. Some scholars believe that breast milk is rich in nutrients and many antibodies against pathogens, giving up breastfeeding is a great loss, and according to statistics, the difference in the rate of hepatitis B infection between breastfed and artificially fed infants is not significant, while the elimination rate of hepatitis B virus in artificially fed infants is not as high as that of breastfeeding. At present, except for “intrauterine transmission”, the horizontal transmission from mother to mother can be basically blocked by implementing hepatitis B vaccine and hepatitis B immunoglobulin to the newborn, therefore, breastfeeding is possible as long as the mother’s nipples do not break and bleed. However, mothers should wash their nipples and hands with soap and water before breastfeeding to reduce the chance of contact transmission.