Objective: To investigate the efficacy and adverse effects of preoperative chemoembolization and the effect of surgical resection on the outcome of intermediate and advanced cervical cancer. Materials and methods: 28 patients with cervical cancer were confirmed by preoperative biopsy histopathology, including 24 cases of squamous carcinoma and 4 cases of adenocarcinoma, 18 cases in the preoperative chemoembolization group and 10 cases in the surgery-only group. All of them had irregular vaginal bleeding with or without pain. Chemoembolization method: Using Seldinger’s modified technique, a 4F Yashiro catheter was introduced through the femoral artery puncture, and the site, size and blood supply of the tumor were first clarified by imaging, followed by super-selective insertion of the microcatheter into the tumor supply artery through the external catheter, and the appropriate amount of chemotherapeutic drug was selected for infusion chemotherapy according to the patient’s condition. After the drug infusion, gelatin sponge particles were injected through the catheter for embolization of the tumor blood supply artery, and the occlusion of the tumor blood supply artery was confirmed by re-imaging, and the parenchyma was free of staining. Postoperatively, hydration and symptomatic treatment were strengthened. Cervical cancer resection was performed 7-10 days after chemoembolization. MRI examination was performed for evaluation before surgery, and the operation time, bleeding volume, tumor resection effect were recorded and compared with the surgery-only group during the operation. The degree of necrosis of tumor cells on tissue sections was observed postoperatively. Results: In the 18 cases of preoperative chemoembolization group, the preoperative MRI examination showed that the tumor volume was significantly reduced, the boundary with the surrounding tissues was clear, and the density heterogeneity was reduced, and the intraoperative mass was significantly reduced, the adhesion with the surrounding tissues was reduced, it was easier to peel off, less bleeding, and the field of view was clear, and all the operations were successful. The main adverse effects were pain, fever nausea and vomiting. Conclusion: The study showed that transarterial chemoembolization can block the blood supply to the tumor and cause ischemic necrosis due to loss of nutrition, which greatly improves the effect of treatment, not only reduces the difficulty of surgery and makes the surgery go smoothly, but also reduces intraoperative bleeding, postoperative recurrence, saves the operation time, and greatly improves the survival time of patients.