The symptoms of patients seen in the outpatient clinic are varied. Some present with fatigue and discomfort in the upper right abdomen, while others come to the hospital because of excessive alcohol consumption and fear of liver disease due to overexertion. There are also patients who come to the hospital because they have a family member with chronic liver disease and are worried that they may also have the disease, or because they have abnormal liver function or fatty liver found during a health checkup. Since chronic liver disease may develop into cirrhosis or liver cancer, it is a very important issue to determine whether the above-mentioned high-risk patients have chronic liver disease. The diagnosis of liver disease is confirmed by a combination of medical history, physical examination, serological tests, ultrasound, and CT. In particular, a face-to-face consultation with a physician is important to clarify and understand the extent of the disease. Telephone and internet consultations, for example, can provide a great deal of assistance to patients, but they cannot replace the most basic diagnostic process. In the case of chronic hepatitis, there are usually no specific symptoms, and even with a physical examination, most of them appear normal. The most accurate way to know if there is chronic hepatitis and how severe the disease is is to do a liver tissue biopsy for pathology. However, liver biopsy is an invasive test that is not easily accepted by most patients. Currently, even without a biopsy, hematology tests can be used to determine the status of the disease in general. However, when antiviral therapy is needed or when there is doubt about the diagnosis and an objective basis is needed, a liver biopsy is required to determine it. Among the hematological tests, the important ones are liver function and hepatitis virus. In liver function tests ALT and AST are enzymes released by damaged liver cells, but are not indicators that correctly reflect the severity of hepatitis. The presence or absence of hepatitis virus infection can be confirmed by serological tests. A positive hepatitis B surface antigen (HBsAg) means infection with the hepatitis B virus, and a positive hepatitis C antibody (anti-HCV or HCV Ab) means a high probability of infection with the hepatitis C virus. A clinical diagnosis of chronic hepatitis can be made when the above indicators are positive plus an elevated ALT in the liver function. In China, about 75% of chronic hepatitis patients are caused by hepatitis B or C virus, so even if there is an elevated ALT, the chance of developing chronic hepatitis will be reduced when the viral indicators are negative. Also, the likelihood of developing chronic hepatitis is greatly reduced when there is no excessive alcohol consumption, no family history, and no high-risk factors such as chronic hepatitis. Currently, most of the patients with elevated ALT alone are caused by fatty liver, but fatty liver does not develop into cirrhosis or liver cancer, so there is no need to worry excessively. Chronic hepatitis often does not differ significantly from normal performance on ultrasound, but when the disease has progressed for a long time, the ultrasound may show a rough liver area. For chronic liver disease, the significance of ultrasound examination is to detect possible early liver cancer, and if there is cirrhosis, ultrasound examination is even more necessary. The clinical manifestations of cirrhosis are varied. It is caused by persistent viral infection damage to the liver tissue, resulting in an uneven surface of the liver. When cirrhosis is uncomplicated, it may be as normal with no abnormalities and is often referred to as compensated liver function. When there are complications, there may be various symptoms such as liver disease face, wasting, and even ascites, which is called liver function loss. The method to confirm cirrhosis is laparoscopy or liver biopsy pathology. In cirrhosis, laparoscopy shows that the surface of the liver is convex and uneven, and liver tissue examination shows liver fibrosis. However, such invasive examinations are not easily accepted by patients. At present, diagnosis can be made mostly through clinical manifestations, serological examinations, ultrasound and CT examinations. In cirrhosis, most of the ALT values are normal or within two times the normal value. In liver function compensation, serum albumin and bilirubin are mostly normal, but often abnormal in decompensation, and the level of these two indexes can roughly reflect the residual number of functional hepatocytes, which is especially important for patients with decompensated cirrhosis. Also, hepatocytes make clotting factors, and if there are not enough functioning hepatocytes, a prolonged clotting time will occur. The prothrombin time (PT) is a direct indicator of clotting time and an indicator of the number of functioning hepatocytes. In liver cirrhosis, the spleen is compensated for enlargement, and platelets are stored in the spleen for too long, and the blood routine often shows a decrease in platelets. About 80% of patients with liver cancer in China have cirrhosis in combination. Therefore, the examination of possible liver oncology should be paid attention to the patients with chronic liver disease during physical examination or follow-up.