The above diagram is the natural process of chronic hepatitis B. The whole process includes four stages, before the age of 20 is the immune tolerance period, this stage is characterized by no conscious symptoms, normal liver function, no abnormal changes in ultrasound, the body is in a state of immune tolerance, no ability to clear the virus by itself, any antiviral treatment at this stage is not ideal, should be regularly observed, waiting for treatment opportunities. 20 to 30 years old is the immune clearance During this period, intermittent weakness, reduced food intake, repeated abnormal liver function, repeated fluctuation of HBV-DNA, ultrasound may have thick liver light spot, large spleen and other manifestations, the body is in an immune active state, with the ability to clear the virus, the treatment effect is better at this stage, you can choose interferon or nucleoside antiviral therapy according to work, life and other physiological conditions. If this stage for treatment, after repeated clearance of the body, may enter the state of low replication of the virus, but this situation is not stable, can again appear repeatedly, in addition the body’s own immune clearance is at the expense of repeated damage to liver cells, in the process of this clearance some have formed cirrhosis or liver failure, which is to enter the fourth stage.