According to the current informed consent form for New Crown vaccination, patients may experience redness, swelling, itching, hard nodules, pain and discomfort at the vaccination site when the vaccination is completed. For the redness, swelling and hard nodules after vaccination, patients can do the following according to their own situation: 1. For local reactions of redness, swelling and hard nodules with a diameter of <1.5cm, generally no treatment is needed and they will subside in 2-3 days; 2. After 24 hours, hot compresses can be applied to speed up blood circulation and promote the receding of hard nodes; 3. When the diameter of redness and hard nodes is >3cm or the local redness, swelling, heat and pain persistently increase, and the local lymph nodes are obviously enlarged and painful, it indicates that secondary infection may occur, and patients should go to the hospital promptly. In addition to the above, patients should also be careful not to press or scratch the local skin to avoid secondary infection caused by bacteria on the surface of hands or clothing. Avoid strenuous arm movements and take rest. And it is best not to take a shower within 24 hours after the vaccination to avoid infection or cold, which may cause more serious discomfort to the body.