Susan is from the United States and came to China 2 months ago to teach English. She is in charge of teaching English to a year group with two other foreign teachers. Before coming to China, she had some Chinese friends in the city where she lived and went to eat Chinese food with them, Susan thought she liked China and wanted to come to this country. So she and her husband sold their house in the U.S. and came to Xiamen together. When she arrived in Xiamen, she found that the Chinese people and the Chinese food here were different from what she had in the United States. Chinese people here don’t greet each other if they don’t know each other, and they don’t even say “hello” when they pass each other. She found that the Chinese food here is also very different from what she ate in the US. Especially at work, she often made plans for the year in the U.S. and rarely changed them, whereas here, she might have to face changes all the time. She regretted that she should not have come to China and lost 5 kg in 2 months. She felt that she was too useless and wanted to terminate her employment contract early and go back to the US. After a friend introduced Susan to Xiamen Mental Health Center and Xiangyue Hospital, she was received by Dr. Lijun Ding, the deputy chief psychiatrist, who made a comprehensive assessment and diagnosed Susan as suffering from depression, giving her antidepressant medication and using a psychotherapy called Interpersonal Relationship Therapy (IPT). Dr. Ding introduced Interpersonal Therapy (IPT) as an effective psychotherapy treatment for depression. Interpersonal relationship therapy (IPT) believes that depression is closely related to interpersonal relationships, and the four main components related to depression include interpersonal loss (death of a significant person in life), interpersonal conflict, interpersonal change (life changes and role transitions) and interpersonal deprivation (loneliness and social isolation). Susan is in the process of interpersonal change. Often depressed people see role change as a loss, and this loss can lead to a sense of failure. Depression often arises when people have difficulty coping with life changes, when their self-esteem and self-identity are threatened, or when they feel challenged beyond their personal abilities or when their lives become chaotic and out of control after a role change. For this situation, Dr. Ding used interpersonal relationship therapy (IPT) to treat the depressive symptoms in the following ways, first linking them to the difficulty of coping with the new life, discussing with Susan the positive and negative aspects of the old role, discussing the advantages and disadvantages of Susan’s work in the U.S., and exploring the feelings associated with the loss of the old role (leaving the U.S.). Also discuss with Susan the positives and negatives of the new role, and explore the feelings that come with the change (after coming to China). Explore the opportunities in the new role. Evaluate the absence objectively. Encourage moderate emotional release (emotional outbursts). Susan was also encouraged to build new interpersonal support and acquire new skills for her new role. This was done by drawing a pros and cons list, objectively analyzing the gains and losses in the U.S. and China, seeing the opportunities and hopes of staying in China, and encouraging her to move to a neighborhood where more foreigners live, to greet them and get to know each other, as well as to learn some simple Chinese and Chinese cultural practices, and to socialize with her Chinese colleagues and friends around her. Through this practice, Susan was able to approach her new role more positively and regained her self-esteem and confidence by acquiring the skills needed for her new role, and gradually all of her depressive symptoms disappeared. In summary, our treatment focused on four main points: evaluating the lost role and mentally letting go of the old one; venting feelings of guilt, anger, and loss; acquiring new skills; and building new interpersonal support. After these therapies, Susan gradually adapted to her life and work in China, made new friends, and now no longer plans to return to China early.