(1) For unvaccinated contacts, administer hepatitis B immunoglobulin (within 24 hours), followed by hepatitis B vaccination (1 week after hepatitis B immunoglobulin). (2) If the contact has been vaccinated but not fully immunized, the full immunization should be made up according to the hepatitis B vaccine immunization procedure after the hepatitis B immune globulin injection. (3) Contacts who have been vaccinated and have developed surface antibodies to hepatitis B should be immunized according to their antibody levels. If the level of hepatitis B surface antibody is sufficient, no treatment is necessary; if the level is not sufficient, a booster vaccination should be given; if there is no response to the initial immunization, one dose each of hepatitis B immunoglobulin and hepatitis B vaccine should be given as soon as possible.