Therapeutic hepatitis B vaccine refers to a new type of vaccine that can break the immune tolerance and rebuild or enhance the immune response in chronically HBV-infected patients, and achieve the purpose of removing hepatitis B virus from the liver cells by stimulating the production of neutralizing antibodies and cellular immune response mainly by cytotoxic T-lymphocyte response in HBV-infected patients. The traditional hepatitis B vaccine is only used for people who are not infected with HBV, and generally only has a preventive effect. On the other hand, the therapeutic hepatitis B vaccine is used for people who have been infected with HBV, and its strength is to “teach” the human immune system to correctly recognize the “enemy”, break the body’s state of immune tolerance, and produce autoantibodies and specific immune response to kill or even eliminate the hepatitis B virus in the body. Hepatitis B virus.