Histopathological examination of the liver is the gold standard for assessing liver fibrosis in chronic liver disease. However, liver biopsy has limited its clinical application because it is an invasive operation, and in recent years, there has been a gradual trend to use several serological and clinical indicators in combination to establish a noninvasive diagnostic model to determine the degree of fibrosis. The age-platelet index (API) and glutathione-glutathione aminotransferase ratio (AAR) are two relatively simple noninvasive diagnostic models for diagnosing the degree of liver fibrosis in chronic hepatitis C. In this study, these two models were applied to chronic viral hepatitis B in China to validate and compare their clinical value in diagnosing the degree of liver fibrosis in chronic viral hepatitis B. Subjects 172 patients with chronic viral hepatitis B hospitalized in our department from June 2006 to March 2008, with a diagnosis in accordance with the Viral Hepatitis Prevention and Control Program developed at the Xi’an Conference in 2000. Patients were positive for hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV DNA) for at least 6 months prior to enrollment, aged between 15 and 68 years, with no history of antiviral and anti-liver fibrosis drug therapy, and co-infection with hepatitis A, C, D, or E virus was excluded. All patients underwent liver histopathological examination, and serum was collected for relevant indexes. Clinical and biochemical parameters were collected and recorded on the day of the liver biopsy or the day before. Laboratory tests The results of alanine aminotransferase (ALT), glutathione aminotransferase (AST) and platelets (PLT) were obtained from routine clinical tests in our laboratory department. Histological examination After routine preoperative laboratory tests, if there were no contraindications, liver aspiration biopsy was performed with the patient’s signed informed consent for liver aspiration biopsy. The liver tissue was fixed, dehydrated, paraffin-embedded, sectioned and stained with hematoxylin-eosin according to the routine operation after fixation, dehydration, paraffin embedding and sectioning, and two pathologists read the films blindly by microscopy. Liver fibrosis was divided into five stages i.e. SO: no fibrosis; S1: expanded fibrosis in the confluent area with limited perisinusoidal and intrafollicular fibrosis; S2: perisinusoidal fibrosis with formation of fibrous septa and preservation of lobular structures; S3: fibrous septa with disturbance of lobular structures without cirrhosis; S4: early cirrhosis [4]. The films were read independently by 2 pathologists blinded, and repeated readings were performed to reach consensus in case of inconsistent diagnosis.