Depression will not directly lead to death, but depression will make people lose the joy of life and will have suicidal thoughts, so many depressed patients will choose to commit suicide, which will lead to the death of the patient. Secondly, depression itself will lower the immune function of human body, so many long-term depressed patients are prone to more physical diseases, such as tumor, cardiovascular and cerebrovascular incidence will increase, tumor and cardiovascular and cerebrovascular diseases will lead to the death of patients, from this level depression will also increase the mortality rate of patients.