Gallstones are a common disease, many people will think: stones are still small, not enough to be a problem …… you will be misled by such a concept? The “big trouble” caused by “small stones” Ms. Liu was found to have small sediment-like stones in her gallbladder during a medical checkup. The actual pain is not as unbearable as biliary colic, but the pain has not been relieved, to the hospital a check is actually acute pancreatitis. The majority of gallbladder stones have a certain range of activity and will move with the change in position. Gallbladder stones can be large or small, single or multiple, and can also get progressively larger. Small stones (0.7-0.8 cm) can easily get stuck in the gallbladder duct and cause acute cholecystitis; larger stones cannot enter the gallbladder duct and are generally less likely to be felt if they are inside the gallbladder; while smaller stones can easily fall into the bile duct and cause more troublesome complications: cholangitis and pancreatitis. （Cholangitis and pancreatitis are two diseases that are much more serious than the gallbladder stones themselves. The smaller the stone, the greater the chance of it falling into the common bile duct, especially in the case of mud-like gallbladder stones. Cholangitis: If the stone falls into the common bile duct, it becomes a blockage of the common bile duct, just like having a slag blocking the drain of the sink, and if it does not go underwater, it will breed bacteria, leading to abdominal pain, jaundice, infection and even shock. Pancreatitis: If a stone falls into the sewer and also blocks the neighbor’s water pipe, the situation will be even worse. The pancreatic duct of the pancreas and the common bile duct share an opening (hepatopancreatic pot belly), and if the stone blocks this opening, the pancreatic juice cannot be discharged and pancreatitis is easily induced, which is a clinical emergency with a high mortality rate. Gallbladder stones are not suitable for lithotripsy, and the best way is gallbladder removal. Gallbladder stones are not quite the same as kidney stones. Kidney stones go through the urinary tract, because the urinary tract is wider, the stones are smaller and may be able to be discharged, so there will be treatments such as stone removal and lithotripsy; while gallbladder stones are different, gallbladder stones go through a narrow exit road, which can easily cause obstruction. Therefore, gallbladder stones can neither be drained nor crushed (the best method is cholecystectomy), and the crushed stones can cause more serious complications, many of which are caused by small stones falling into the common bile duct and causing blockage. Cholecystectomy is an effective treatment for gallbladder stones, and the current widely performed surgical procedure at home and abroad is laparoscopic cholecystectomy, which has basically replaced the traditional open cholecystectomy. It is worth mentioning that in a large proportion of patients, the gallbladder has become “porcelain” in the process of long-term inflammation and has no normal physiological function, so it is useless to stay and is prone to problems. In case of emergency surgery, it is not safe and there is a high chance of complications, so it is better to treat gallbladder stones when they are not yet causing symptoms or complications.