Common medications for motor neuron disease are riluzole and edaravone. In addition to medication, the treatment should be accompanied by respiratory support and psychotherapy. Currently, this disease is limited to symptomatic treatment, and does not really eradicate the cause of the disease. The disease is a heterogeneous group of diseases, the causative factors are diverse and interact with each other, there is still a lack of effective treatment, only through symptomatic treatment and drug therapy to alleviate the symptoms and alleviate the patient’s pain. Early motor neuron disease can take riluzole, edaravone, etc. The efficacy of riluzole is mainly through the inhibition of glutamate secretion, so as to achieve the purpose of delaying the course of the disease and prolonging the survival rate of patients. Edaravone can scavenge oxygen free radicals. In the later stages, attention should be paid to the respiratory support of the patient and non-invasive bi-level positive pressure ventilation should be applied at an early stage to assist respiration. For the different stages of motor neuron disease, psychological problems will have different manifestations, such as depression, anxiety, insomnia, communication disorders, etc., according to the patient’s specific situation to give targeted guidance and treatment. In general, it is recommended that patients use medication under the guidance of a doctor, not blindly self-medication, should be early diagnosis, early treatment, as far as possible to extend the survival of patients.