The differences between myasthenia gravis and motor neuron disease are as follows: First, the nature of the disease is different, myasthenia gravis is an autoimmune disease caused by transmission disorders at the neuromuscular junction, motor neuron disease is a neurological degenerative disease caused by damage to the anterior horn of the spinal cord, motor cells and brainstem motor neurons; Second, the clinical manifestations of myasthenia gravis and motor neuron disease are different, myasthenia gravis patients appear The clinical manifestations of myasthenia gravis and motor neuron disease are different. Patients with myasthenia gravis have droopy eyelids, blurred vision, diplopia, strabismus, etc. As the disease progresses and worsens, patients develop respiratory muscle weakness, while patients with motor neuron disease have upper and lower motor neuron involvement as the main manifestation, and in severe cases, patients develop respiratory muscle paralysis and have to use ventilators to assist breathing; third, the treatment of myasthenia gravis and motor neuron disease is different. The patients with motor neuron disease should be given neuroprotective and supportive treatment as early as possible.