Early symptoms of motor neuron disease generally consider a gradual increase in weakness of the limbs, mainly from the end muscles of the upper limbs to the trunk. Motor neuron disease is sporadic, insidious, and slow progressing, often gradually spreading from one side to the opposite side, and damaging upper and lower motor neurons at the same time. Early symptoms are common for unilateral or bilateral finger movement disorder, clumsiness, followed by the size of the interosseous muscles, earthworm muscles and other hand muscles weakness, muscle atrophy phenomenon, can be eagle-claw shape, and gradually involved in the arm, scapular muscle groups, can be extended with the course of the disease involved in the torso and the neck, and sometimes the patient may be manifested as dysarthria, choking on drinking water, and so on. When the patient has motor neuron disease, according to the symptoms of the appropriate treatment, specific can consult a professional physician’s opinion.