Symptoms of motor neuron disease are characterized by different combinations of muscle weakness, atrophy and cone beam signs due to the different sites of damage, mainly including amyotrophic lateral sclerosis, progressive muscular atrophy, progressive medullary palsy, and primary lateral sclerosis. Patients are advised to seek immediate medical attention and actively cooperate with doctors for treatment. 1. amyotrophic lateral sclerosis: upper and lower motor neurons are damaged, manifested by muscle weakness, atrophy and cone beam sign, the whole body muscles can be involved, the affected parts often have obvious muscle bundle tremor, patients generally do not have objective sensory impairment. 2. Progressive myasthenia gravis: the damage is limited to the anterior horn cells of the spinal cord, manifested by weakness and atrophy without cone-bundle sign. In the later stages of the disease, the patient may even be unable to take care of himself, have difficulty in breathing, and eventually terminate his life due to loss of lung function. 3. Progressive medullary palsy: Damage to the medullary motor nerve nuclei alone manifests weakness and atrophy of the pharyngeal and lingual muscles, and the patient will have difficulty in pronouncing words, hoarseness and other symptoms. 4. Primary lateral sclerosis: only the pyramidal fasciculus is involved and manifested as weakness and pyramidal fasciculus sign. The common first symptom is symmetrical stiffness and weakness of both lower limbs, and walking with scissor gait. It progresses slowly and gradually involves both upper limbs. The muscle tone of the limbs is spasmodically increased, the tendon reflexes are hyperactive, and the pathological reflexes are positive. It is recommended that the patient seek immediate medical attention and follow the doctor’s instructions for respiratory support, nutritional support, and the use of coenzyme Q10 and neurotrophic factor in order to correct the patient’s symptoms. It is recommended that patients with motor neuron disease maintain a positive and optimistic mood in their lives, while cooperating with their doctors for active treatment.