It is easier to diagnose gallbladder stones with typical symptoms, but because some patients with gallbladder stones have little or mild symptoms and no obvious gallstone features, they will take some detours in diagnosis and fail to detect them early. For example, many patients with gallbladder stones are often treated as gastritis, gastric ulcer or indigestion because of upper abdominal discomfort, stomach fullness, belching and poor appetite before gallbladder stones are detected, and they take medicine for gastric diseases for a long time, but with little effect. Once the diagnosis is clear, the treatment can be targeted and the results are naturally good. The main diseases that are very similar to gallbladder stones are the following: (1) Liver diseases: such as viral hepatitis, hepatic steatosis, etc. (2) Gastrointestinal diseases: such as gastrointestinal dysfunction, peptic ulcer, high location appendicitis and right-sided colon disease. (3) Biliary tract diseases: such as biliary tract dysfunction, gallbladder tumors, gallbladder polyp-like lesions and biliary parasites, etc. (4) Others: such as right-sided pyelonephritis, herpes zoster and radiculitis, etc. Since the above diseases are easily confused with gallbladder stones, patients are requested to tell the occurrence and development of their diseases systematically and carefully during the consultation so as to provide sufficient information to the doctor’s diagnosis. Likewise, the doctor should take a comprehensive medical history, perform various relevant examinations in detail, and analyze the obtained information comprehensively to confirm the diagnosis in time as far as possible.