Cancer is one of the most common diseases that threaten human life. The most important feature of cancer is that the cells are uncontrolled and grow indefinitely, and it is metastatic and can invade other tissues of the body. The liver is the largest gland in the human body and receives blood supply from both the hepatic artery and portal vein, and the blood flow from the digestive tract organs all flows back through the portal vein, making it a common site for cancer metastasis. About one-third of tumors can metastasize to the liver. So what are the parts of tumors that are prone to metastasis to liver? What are the characteristics of metastatic liver cancer? And how to treat it? Let’s talk about the problems related to metastatic liver cancer. Metastatic liver cancer can be detected by ultrasound, CT, MRI, and can be verified by liver aspiration. Metastatic liver cancer usually does not have elevated AFP, while primary liver cancer has elevated alpha-fetoprotein AFP. It can also be further differentiated by AFU with rocket alglucosidase. Metastatic liver cancer: Metastatic liver cancer, also called secondary liver cancer, is formed when the primary focus originates from other organs in the body and metastasizes to the liver. We have said that cancer metastasizes through four ways: hematogenous metastasis, lymphatic metastasis, direct invasion and implantation metastasis. Among them, hematogenous metastasis is the most common for metastatic liver cancer. According to statistics, almost all tumors, except brain tumors, can metastasize to the liver. The most common are gastrointestinal tumors: gallbladder cancer, colorectal cancer, gastric cancer and pancreatic cancer in that order. Tumors of the chest: lung cancer as well as esophageal cancer. Other common ones are breast cancer, ovarian cancer, and melanoma. More than 50% of colorectal cancer patients will develop liver metastases. When the primary cancer has metastasized to the liver, it means that the primary cancer is advanced. Although it is advanced, it is not untreatable. Surgical resection and radiofrequency ablation are the most effective methods to treat metastatic liver cancer. Other treatments include arterial chemoembolization (TACE), anhydrous alcohol injection (PEI), biologic therapy, Chinese medicine, and so on. These treatments alone or in combination are the key to cure or prolong the life of patients.