If yellowing of the palms occurs while taking western medicine, one needs to be alert to the problem of drug-related hepatitis. If the yellowing of the hands is noticeable, you can bring the medication box you are taking to the hospital and have your liver function checked with a blood sample. Be careful not to stay up late the day before the liver function check, eat a light diet, and fast before having blood drawn the next day. If the cause is determined to be medication, the medication may need to be adjusted and, if necessary, changed.