Yellowing of the palms of the hands can be a problem caused by disease or by food.
A variety of diseases can cause jaundice in the body, which can be severe enough to cause yellowing of the skin on the palms of the hands, as well as jaundice that can cause yellowing of the sclera and mucous membranes; certain diseases or carotenemia caused by long-term consumption of foods such as pumpkin and carrots that contain a high carotenoid content can also cause yellowing of the palms of the hands, but not the accompanying yellowing.