With the improvement of people’s living standards and changes in dietary habits, the number of people suffering from gallstones is increasing year by year. The cause of gallstones is still unknown, but the more recognized view is that it is related to personal eating habits, such as long-term high-fat diet, less vegetables and fruits, etc. Not eating breakfast is also a factor in the formation of gallstones. Individual differences in the human body are also an important factor, as we often see some teenage patients with gallstones in the clinic. In normal people, the gallbladder is located in the upper right abdomen, so the symptoms of gallbladder stones are mainly manifested in the upper right abdomen. If the gallbladder stone is larger (diameter greater than 1 cm), the patient may show intermittent right upper abdominal pain, and also right shoulder and back pain, accompanied by loss of appetite, can not eat greasy diet, serious cases may appear nausea, vomiting, fever. If the diameter of the stone is between 0.5cm and 0.8cm, it may get stuck in the outlet of the gallbladder, forming what is medically called “stone impaction”, making it difficult to drain the bile from the gallbladder, resulting in extreme dilatation of the gallbladder, and in severe cases, septicemia and necrosis of the gallbladder. The embedded stone can also compress the common bile duct and cause necrosis of the common bile duct, or cause obstruction or partial obstruction of the common bile duct, resulting in yellowing of the skin and mucous membranes all over the body, making the treatment quite difficult. Another serious consequence is acute pancreatitis caused by gallstone disease, which is a life-threatening disease formed when gallstones between 0.3cm and 0.5cm in diameter are stuck in the exit of the bile duct into the intestine with the bile discharge, causing obstruction of pancreatic juice discharge. Gallstones are one of the major causes of acute pancreatitis, and in China, acute pancreatitis caused by gallstones accounts for more than 80%. Acute pancreatitis mainly manifests as sudden onset of epigastric pain, accompanied by nausea, vomiting, fever, and if large acute necrosis of the pancreas occurs, acute death of the patient can occur. Currently it is quite difficult to treat acute necrotizing pancreatitis at home and abroad, and despite continuous improvement in treatment, the mortality rate is still as high as 40% to 80%. In addition, if gallbladder stones are not treated, there is a possibility of gallbladder cancer. The diagnosis of gallbladder stones is mainly made by ultrasound examination, and the correct diagnosis rate can reach more than 90%. The effective treatment for gallbladder stones should be surgical removal of the gallbladder to completely remove the root cause of gallbladder stones. Traditional cholecystectomy is more invasive and is generally used for patients with severe complications. Laparoscopic surgery is now routinely performed, and this type of surgery is less invasive, recovery is quick, and the patient is able to get out of bed the day after surgery. After gallbladder removal, there are usually no adverse effects on the body. Some people say that gallbladder removal can cause stones to metastasize to the bile ducts and liver, which is a misconception. Even if the gallbladder is not removed, the patient will still have stones in the bile ducts and liver, which is related to the individual differences of the patient and has nothing to do with the surgery. Surgery is a “scary” thing for the patient, therefore, in the early stages of the disease, people often choose to take medication to remove stones. However, due to the special structure of the biliary tract, there are not many drugs that can really expel stones and drain them, and these drugs are only effective for anti-inflammatory and pain relief. Many patients often have to choose surgery after taking medications for a long time that are ineffective. Early surgery not only prevents serious complications from occurring, but also saves money that would have been spent unnecessarily. The best treatment is prevention. Changing dietary habits, eating less greasy diet, eating more vegetables and fruits, changing the habit of skipping breakfast, strengthening physical activity and avoiding weight gain are all good ways to prevent gallstones.