1. What is artificial insemination? Concept: It is a method of placing male sperm into the female reproductive tract in a non-coital manner to allow natural union of sperm and egg to achieve conception. There are artificial insemination by husband (AIH) and artificial insemination by donor (non-spouse) (AID). Our center only performs AIH with husband’s sperm. 2.What is IVF? Concept: It is a procedure in which eggs are removed from the mother’s body and placed in a Petri dish, sperm is added which has been preferentially induced and treated to fertilize the sperm-egg in vitro and develop into a pre-embryo which is then transferred back to the mother’s uterus and the baby is delivered after pregnancy. Since the embryo is developed in the test tube for the first 2 days, it is also called IVF technique. 3.Indications for artificial insemination? (1) Male partner with few, weak or deformed sperm, sexual dysfunction, etc. (2) Female partner with cervical factor (3) Immune infertility (4) Unexplained infertility Prerequisite: Female partner has at least one side of the fallopian tube open, if it meets the indications for IUI, it takes 1-2 months from the beginning of preparation to the end of conventional treatment. 4.What are the conditions for IVF? (1) Gamete delivery disorders caused by various factors in the female partner Such as bilateral tubal obstruction, tubal agenesis, severe pelvic adhesions or history of tubal surgery and other loss of tubal function. (2) Infertile patients who have had their fallopian tubes removed after ectopic pregnancy or who have been treated conservatively but have fallopian tube obstruction or damaged function (3) Ovulation disorders Refractory ovulation disorders that have not resulted in pregnancy after repeated conventional treatment, such as repeated ovulation induction or COS, or after treatment with intrauterine insemination techniques. (4) Endometriosis resulting in infertility and failure to achieve pregnancy after conventional drug or surgical treatment. (5) Low, weak, and malformed sperm in the male partner Male infertility with low, weak, and malformed sperm or a combination of factors, and still no pregnancy after treatment with intrauterine insemination technique, or the severity of the male factor is not suitable for intrauterine insemination. (6) Those with unexplained infertility who have repeatedly failed to obtain pregnancy through intrauterine insemination or other conventional treatments. 5.Can I choose twins for assisted reproduction? Can I choose male and female? In many cases, two embryos can be transferred for IVF. The specific situation needs to be analyzed by the doctor according to the age of the couple, the number of years of infertility, the physical condition, the financial status, the patient’s wishes, etc. and finally decided after communication with the patient. The gender selection is not yet possible in China, so if any place says how many wallets to give birth to boys and girls, please be careful of being deceived. 6.How much does it cost to do IVF and IUI? Is success guaranteed? (1) artificial insemination: the total cost of artificial insemination is about 6000 for one cycle, including examination and medication for both men and women. If you are unsuccessful once and do it again next time, the total cost is only 1500 RMB for the procedure if your previous examination is not expired (some of the examination sheets are expired in half a year and some in a year). (2) IVF: It varies according to the patient’s age and medication regimen. Including the examination and medication, etc., generally ranging from 20,000 to 35,000 yuan, the above costs are for reference only. If one time is unsuccessful, if you have extra embryos frozen in our center in the pre IVF period, the next transfer can be much less expensive. If you have no extra embryos frozen for the first time and your previous checklist is not expired (some of the checklists are expired in six months and some in one year), it can also reduce the cost a lot. (3) There is no guarantee of success in any formal medicine, but we can usually provide you with past success rates and expected success rates for your reference. If any place says that the success is guaranteed, please be careful not to be fooled. 7.What documents should I prepare before the artificial assisted reproduction? (1) Required documents include: ID card of both parties, marriage certificate, original family planning service certificate of the woman, and if you have already had one child, you need to have a certificate of permission to have a second child. (2) About the family planning service certificate: ①If the woman’s household is in the city, the family planning service certificate should be applied for in the street office where the woman’s household is located; if the woman’s household is in the rural area, it should be applied for in the village committee where the woman’s household is located. ②If both men and women are of non-Chinese nationality, no family planning service certificate is required; as long as one of the parties is of Chinese nationality, the family planning service certificate is required to be provided by the party with Chinese nationality. (3) Document requirements: ① The last audit of the birth control certificate (or certificate of permission to have a second child) is valid for one year; ② The names and ID numbers of the three documents are the same; if they are not the same, a certificate must be issued at the local police station to prove that they are the same person, otherwise the assisted conception treatment cannot be performed. 8. How long does it take to determine to do IVF treatment? What is the process? The whole process takes about 2-3 menstrual cycles. The normal pre-IVF examination is 2 weeks, blood will be drawn on the 2nd-4th day of menstruation, vaginal discharge test will be performed after menstruation is clean, and medical records will be created with all the information (three certificates and test sheets) after the information is complete. On the 20th-23rd day of menstruation, we will start IVF-ET treatment with GnRHa (down regulation injection), 14-18 days after down regulation, we will start ovulation injection, ultrasound monitoring of follicles, 9-14 days after routine ovulation, the follicles will be big enough to start night injection of HCG, 34-36 hours after HCG injection, the female will get eggs and the male will get sperm, usually after 3 days we will perform transplantation, 14 days after transplantation. Blood will be taken for HCG to determine if pregnancy is present.