In the late stage, there may be progressive jaundice, changes in urine and stool color, loss of body mass, significant skin pruritus and abdominal masses. Diagnosis: 1. imaging; 2. elevated bilirubin and alkaline phosphatase; 3. elevated CEA and CA19-9, with low specificity and sensitivity. Treatment and prognosis 1.Treatment Surgical resection is the main treatment in the early stage; stenting is performed in the late stage to reduce bile duct obstruction and systemic chemotherapy. 2.Prognosis: 5-year survival rate is 5% Image performance 1.X-ray performance X-ray film: generally not used to diagnose gallbladder cancer ERCP: limited value, the gallbladder usually does not appear, the common hepatic duct and intrahepatic bile duct dilatation can be seen 2.CT performance CT scan: 20% show a mass in the lumen of gallbladder, 20% show focal or diffuse thickening of gallbladder wall, 60% show a mass replacing the whole gallbladder. Most of them are hypodense or isodense; high density may be seen, either as gallbladder stones or ceramic-like gallbladder, or as foci of calcification within the tumor. CT enhancement: 40% of tumors show significant vascular-like enhancement (higher than that of their own normal liver parenchyma); significant enhancement in the arterial phase and persistent or decreasing enhancement in the portal phase; (The degree of enhancement in the portal phase is related to the proportion of fibrous tissue contained in the lesion.) When the lesion is large, the peripheral part of the lesion shows significant uneven enhancement in the early arterial phase; the lesion often involves the neighboring liver parenchyma or structures in the portal area. 3.MR performance T1WI: low signal or isosignal in the gallbladder lumen. T2WI: slightly high signal predominates. T1WI enhancement: similar to CT enhancement; obvious enhancement in the arterial phase with heterogeneous slightly high signal; persistent enhancement in the portal phase or delayed phase; more sensitive than CT to show whether the tumor has invaded the neighboring liver. MR functional imaging: Tumor spread is limited, and DWI often shows high signal; MRCP shows the anatomical relationship of biliopancreatic duct, and is more sensitive to gallbladder cancer that infiltrates the bile duct.