The exact cause of gallbladder cancer is still unclear, but it is generally believed to be related to chronic cholecystitis and gallbladder stones, probably due to the long-term chronic stimulation of stones, resulting in mucosal hyperplasia and degeneration of gallbladder and then cancer. Gallbladder cancer mostly occurs in the body of gallbladder, and invasive adenocarcinoma is the most common, with high malignancy, rapid growth, early and extensive metastasis, which can directly infiltrate into the adjacent liver, duodenum, transverse colon and other tissues, as well as metastasize to the gallbladder duct and lymph nodes around the hepatoportal.