Although the incidence rate of gallbladder cancer is much lower than that of liver cancer and pancreatic cancer, the prognosis of gallbladder cancer is comparable to or even worse than these two types of cancer, because patients with gallbladder cancer are often accompanied by gallstones and chronic cholecystitis, which are easily confused with these diseases in the early stage and are often diagnosed at an advanced stage. The prognosis of gallbladder cancer is very poor, how can the early diagnosis rate be improved? Gallbladder cancer tends to occur in middle-aged and elderly women, and patients with previous gallstones, especially those larger than 2cm or filled stones, long history of chronic cholecystitis, significant thickening of gallbladder wall, gallbladder atrophy, or polyp-like changes of more than 1cm, are recommended to be closely reviewed and, if necessary, preventive removal of gallbladder.