Recently, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine successfully completed the first transumbilical single-hole laparoscopic cholecystectomy in Shanghai, making it a reality that no trace is left in the abdomen after gallbladder stone surgery, which not only reduces the complications of surgery, but also removes the mental distress after surgery for many patients, achieving another leap in the technology of laparoscopic surgery application. Minimally invasive laparoscopic techniques have been widely used in clinical practice and have brought great changes to the field of surgery due to small skin incisions, fast recovery and less pain. In order to minimize surgical trauma, the procedure has evolved from the classic four-hole technique to the current conventional three-hole technique and the few two-hole techniques in recent years. The first single-port laparoscopic cholecystectomy in Shanghai was performed at Xinhua Hospital under the organization and guidance of Liu Yingbin, director of the Department of General Surgery, with Associate Professor Tang Zhaohui, M.D., as the chief surgeon. The patient, Ms. Zhang, had been suffering from gallbladder stones for many years and finally made up her mind to have her gallbladder removed, and on May 27, Associate Professor Tang Chaohui performed the single-port laparoscopic cholecystectomy through the umbilicus in less than one hour. This technique enters the abdominal cavity through the umbilical port and uses the umbilical crease to conceal the surgical incision, so there is no obvious surgical scar on the body surface. At the same time, the incision pain is reduced due to the reduction of poking holes. The post-operative recovery is fast, especially the patient’s psychological feeling is further improved. After the surgery was completed, Ms. Zhang could hardly believe that she could not find any wound in her abdomen and felt very satisfied. Director Liu Yingbin introduced after the surgery that with the continuous improvement of living standard, people’s requirements for disease treatment are increasing, and there are higher requirements for minimally invasive and cosmetic surgery based on the pursuit of surgical safety, which has caused increasing attention in the field of surgery. Single-port laparoscopic surgery through the body’s inherent channel “umbilicus” can basically achieve cosmetic results without scarring on the body surface. However, the technical requirements of the surgery have been greatly improved. In the past, the four-hole and three-hole classical laparoscopic surgical approaches were used in clinical practice, which required the use of the surgical angle of the operating instruments to complete the laparoscopic surgery. Although many special instruments have been tried for many years, few of them have been successful and difficult to be clinically promoted. With years of rich experience in minimally invasive surgery, Associate Professor Tang Zhaohui successfully completed the operation with conventional laparoscopic instruments, demonstrating Xinhua Hospital’s pursuit of cutting-edge surgical technology and the “people-oriented” spirit of unremitting efforts to reduce patient trauma and pain. In the near future, innovative techniques such as transumbilical single-port laparoscopic liver cyst opening and appendectomy are also being carried out in succession.