Ozone in medical clinical applications

  What is ozone?
  Ozone (is an isomer of ozone, a molecule composed of three oxygen atoms, which has a very strong oxidizing effect, so it is also known to be the most active oxygen, which is a component of the natural atmosphere. Ozone has a very high energy, so it is very unstable and at room temperature and pressure the molecular structure is easily changed and quickly decomposes itself into O2 and individual oxygen atoms. Single oxygen atoms are very active and have a strong oxidizing effect on bacteria, viruses and other microorganisms.
  What is the role of ozone in human body?
  (1) Ozone helps the liver to perform basic detoxification.
  (2) It can promote the breakdown of fats (cholesterol and triglycerides). Fat is a major contributor to cardiovascular disease (heart disease and stroke).
  (3) It can significantly promote cell metabolism and enhance the energy of the body.
  (4) It can break down and greatly reduce uric acid (uric acid is the main substance that causes gout and is harmful to blood vessels).
  (5) It can improve blood flow and reduce the production of circulatory system diseases and related diseases.
  (6) It can increase the oxygen-carrying capacity of red blood cells in the blood by reducing their coagulation and thus improve blood flow margins.
  (7) It can increase the oxygen supply of blood to tissues and promote better absorption.
  (8) It is able to kill various bacteria, viruses and fungi and inhibit their repopulation; it is particularly effective in recurrent and aggravated viral diseases.
  The development process of ozone treatment of diseases
  1826 The earliest written mention of ozone as an antiseptic was published.
  1870 The first reports of ozone purification of the blood appeared.
  1885 The first book detailing the medical uses of ozone, “Ozone,” is published.
  1898 The Ozone Therapy Association was founded in Berlin.
  1966 In Germany, he was awarded the Nobel Prize for this research.
  In 1980, the German medical community organized a study on ozone therapy by 644 therapists and analyzed the results of 579,238 treatments performed on 38,475 patients and found that only 40 side effects occurred, a percentage of 0.000007%, some of which were indirectly caused by complications of other diseases, indicating that ozone therapy is the safest.
  Nowadays, since the biochemical and physiological effects of ozone have been proven, ozone therapy is gaining more and more attention as a new treatment modality by medical practitioners around the world. To prove its safety, ozone has been used in clinical medicine for many years and has been used for millions of visits for different diseases.
  The medical functions of ozone
  There are five major medical functions of ozone and as many as six treatment methods, each of which is described as follows.
  I. Ozone (O3) can kill bacteria, fungi and viruses quickly and completely
  Ozone inactivates viruses by directly destroying the ribonucleic acid (RNA) or deoxyribonucleic acid (DNA) of viruses; ozone kills bacteria and fungi by directly destroying the cell membranes of bacteria and fungal microorganisms, and then destroying the tissue within the membranes to complete the process. The powerful killing effect of ozone on bacteria, fungi and viruses often overshadows many of the antibiotics being used in clinical practice.
  Ozone also stimulates the proliferation of leukocytes and enhances the phagocytosis of granulocytes, which in turn stimulates the formation of monocytes, all of which contribute to the killing of bacteria, fungi, and viruses.
  Ozone also activates T-cells and promotes cellular production of interferon. Clinical studies have confirmed that when the therapeutic concentration of ozone reaches 50ug/ml, interferon in the serum can reach its maximum value, and interferon can accelerate the healing of viral and bacterial infections.
  Second, ozone (O3) can oxidize cholesterol and various toxic substances
  Scientific experiments show that: ozone can make the double bond of cholesterol break and oxidize i to 4b-2.4-dinitrophenylhydrazone, referred to as hydrazone 4b, which is the conclusive evidence found by British medical experts through biochemical experimental means. The discovery of this yo, medical function of ozone provides a safe and effective and completely drug-free treatment for the treatment of patients with high blood lipids, high blood density and cardiovascular diseases and the preventive health care of sub-healthy people. The clinical study of foreign scholars reported that: after 5 times of ozone treatment, cholesterol and LDL can be reduced by 5.7% and 14.8% respectively, and after 15 times of treatment, they can be reduced by 9.7% and 19.8% respectively; the study of clinical medical workers in China is not only consistent with the situation reported abroad, but also observed that the condition of lipid change is closely related to the concentration of ozone during treatment and the number of times of ozone treatment. The number of ozone treatments is closely related to the concentration of ozone during treatment.
  As a strong oxidant second only to fluorine, ozone can decompose various wastes and toxic substances produced by the body’s metabolism, such as ozone can decompose harmful substances produced by disease-causing microorganisms; ozone can help detoxify the liver; ozone can also react with abnormal mineralized substances such as uric acid and stones through oxidation, change their solubility, improve the body’s metabolic level, and then discharge harmful substances from the body. Ozonated saline has a more desirable therapeutic effect on co poisoning, pesticide poisoning, etc.
  Ozone is analgesic and has no toxic side effects or addiction
  Clinical studies have concluded that ozone can increase the activity of erythrocyte glutathione peroxidase and glucose 6-phosphate dehydrogenase, thus enhancing the lipid peroxidation reaction, and using this principle, intravenous input of ozonated saline is effective in the treatment of migraine; Bocci et al. also speculated that the analgesic effect of ozone injection with fine needles for the treatment of lumbar disc herniation may be similar to that of “chemical acupuncture”. Bocci et al. also speculated that the analgesic effect of ozone injection with fine needles for lumbar disc herniation may be a mechanism of action similar to “chemical acupuncture”, which can stimulate the release of enkephalins and other substances from inhibitory interneurons to achieve analgesia.
  Ozone can also inactivate pain-causing substance P in the body, so it is effective in treating all kinds of pain, including pain of unknown origin. For patients with advanced cancer, ozone macroauto-therapy or ozonated saline sedation can significantly reduce cancer pain and discomfort, and can improve patients’ mental status, sleep, and energy level, and although it cannot ultimately cure, patients’ quality of life can be greatly improved.
  In addition, ozone therapy has very satisfactory therapeutic effects on rheumatoid pain, diabetic foot pain, vasculitis pain and various unexplained pains. At present, the main pain medications used in clinical application are non-steroidal drugs and morphine drugs. All of them have toxicity and addiction, which limit their clinical application. Ozone therapy is not only effective, but also has no side effects and addiction, and there is no toxicity if the concentration is used according to medical advice.
  Ozone can stimulate and enhance the immune function of the body
  Ozone can react with unsaturated fatty acids on the surface of immune cells to generate lipid peroxide chains, which can activate the nuclear factor NFKD when it enters the cells, thus activating cellular MRNA replication, transcription and translation, promoting protein synthesis and the release of cytokines (interferon and interleukin), and enhancing the immune function of the body.
  V. Ozone can rapidly change the hypoxic state of the body tissue
  Ozone can increase the content of 2,3-diphosphoglycerol (2,3-DPG) and reduce the affinity of red blood cells for oxygen, which means that red blood cells can release oxygen more easily and enhance the oxygen supply to body tissues; ozone can also increase the deformation ability of red blood cells and improve blood rheology.
  Ozone, whether it enters the body with the transfused blood, or enters the cavity or contacts the lesion site via direct inflation, has the function of providing oxygen to each corresponding tissue of the body and improving the local or systemic hypoxia. Ozone entering the circulation then supplies oxygen to oxygen-demanding tissues as dissolved oxygen or hemoglobin-bound oxygen; ozone decaying in contact with local lesions can also supply oxygen directly to ulcerated tissues. Therefore, ozone therapy also has the functions of improving blood rheology and hemodynamics, reducing red blood cell agglutination and platelet aggregation, reducing circulatory disorders, enhancing the function of red blood cells, improving the ability of blood to pass through capillaries and increasing vascular elasticity, etc. Therefore, it has good effects on the prevention and improvement and treatment of cardiovascular and peripheral vascular diseases.
  If the five medical functions of ozone can really play its role in clinical treatment, it will definitely rewrite the status quo of today’s clinical medical treatment which is completely dependent on drug treatment, and this may trigger a change of clinical medical concept and clinical treatment technology.