This question is commonly seen in the clinic and many patients will come in with biochemical test sheets. High blood levels are treated with medication in addition to exercise, diet control, and for some patients. Again, the starting line for this treatment cannot be indicated by a fixed value. Pharmacological treatment of hypercholesterolemia is determined by the patient’s other underlying conditions. According to the Chinese Guidelines for the Prevention and Treatment of Dyslipidemia in Adults, the threshold for cholesterol treatment takes into account the patient’s gender, age, presence of hypertension, diabetes, coronary heart disease, stroke, peripheral arterial disease, and many other conditions. For very high-risk groups (patients with acute coronary syndromes (including myocardial infarction and unstable angina) or ischemic cardiovascular disease combined with diabetes), the LDL cholesterol target value should be controlled below 2.07 mmol/L. For high-risk groups (those with coronary heart disease or other critical conditions, or 10-year risk greater than 10%-15%), the target value should be 2.59 mmol/L or less. The medium-risk group (10-year risk of 10%-15%) should be controlled at 3.37 mmol/L or less. The low-risk group (10-year risk less than 5%) should be controlled at 4.14 mmol/L or less. Therefore, the need for medication in patients with hypercholesterolemia should be determined on a patient-by-patient basis.