Familial hypercholesterolemia, because of its severe symptoms, often leads to severe hypercholesterolemia in children, yellow tumors, coronary heart disease often during adolescence, and even life-threatening conditions. Therefore, early genetic diagnosis and screening of patients with familial hypercholesterolemia is essential. First of all, genetic diagnosis is the “gold standard” for the final diagnosis, not only for the patient, but also for the relatives who are related to the patient. In turn, targeted treatment can be administered. This will prevent coronary heart disease and improve the quality of life. Furthermore, patients with genetic diagnosis can be treated with “precision” according to their specific conditions. There are various choices of lipid-lowering drugs currently used in clinical practice, and the PCSK9 inhibitor that will enter the clinic soon provides a new weapon for patients with familial hypercholesterolemia, and is likely to become a gospel of lipid-lowering treatment for patients with familial hypersterolemia. My team at Anzhen Hospital and Prof. Luya Wang are committed to clinical and basic research on this disease and do our best to provide the most standardized diagnosis and treatment for patients. Finally, children with familial hypercholesterolemia are a misfortune for families because of their severe symptoms and the difficulty of curing them, and some parents even dare not have any more children because of this. Genetic testing can prevent the possibility of congenital carriage of the disease-causing gene mutation by examining the parents for eugenics. Anzhen Hospital, as the Beijing Institute of Cardiovascular Diseases and the National Clinical Research Center of Cardiovascular Diseases, cooperates with the Department of Obstetrics and Gynecology of Peking Union Medical College Hospital and Peking Medical College Hospital all year round to carry out eugenics for patients with familial hypercholesterolemia, so that such families can say goodbye to their worries and have a healthy and lively baby.