Low-density lipoprotein cholesterol (LDL-C) is a commonly used indicator of blood lipids in our biochemical tests and is currently considered to have the highest correlation with atherosclerotic disease. Therefore, we need to actively control LDL-C. Lowering LDL-C usually involves two aspects: Lifestyle control: For most people, elevated blood lipids, including LDL cholesterol, are mainly related to excessive intake and low metabolism. The focus is on reducing cholesterol intake, and common foods with high cholesterol content include: animal offal, including brain, liver, intestines, etc., and some mollusks, such as octopus, squid, etc.; more fish, dietary fiber-rich foods, and vegetable oils with low cholesterol content can be consumed. For more details, please refer to “What to eat for high triglycerides”. Drug control: In addition to lifestyle control, some people have high cholesterol levels due to related diseases, poor dietary control or have developed atherosclerosis-related diseases, which require the use of appropriate drugs. Currently, the most important drugs for LDL cholesterol reduction are statins, the main effect of which is to inhibit LDL cholesterol synthesis in the liver; if statin therapy alone does not achieve the LDL-C target, cholesterol absorption inhibitors can also be applied. It should be noted that for most patients who need medications to lower LDL-C, statins need to be taken for a long time and may cause rebound once they are discontinued; in addition, a small number of patients may experience side effects from taking statins, so they need to be taken regularly and tested for safety under the guidance of a physician. Lowering LDL cholesterol depends first of all on lifestyle, especially diet control; on top of that, medication control should be carried out under the guidance of a doctor according to the individual’s specific situation. Early reduction of LDL cholesterol to a safe target can delay and prevent the onset of related atherosclerotic diseases.