March back to the United States, and some friends together to get barbecue, the face of fat chicken wings, fragrant grilled squid, friends cheered: “Let go of the food, the United States has lifted the ban on cholesterol ……!” What’s going on? According to reports, “The 2015 edition of the Dietary Guidelines for Americans has removed the standard recommendation of 300 mg of daily cholesterol intake, and the Dietary Guidelines Advisory Committee (DGAC) believes that food intake of cholesterol will no longer be a concern. The reasoning is that although high cholesterol foods such as egg yolks, animal offal, etc. have long been considered a factor in raising the risk of cardiovascular disease, scientific studies over the years have not found a clear causal relationship between the two. Due to the continued lack of clear scientific evidence and the fact that the body often produces much more cholesterol than is contained in the diet, the DGAC ultimately decided to discontinue cholesterol as a “nutrient of concern for excessive intake. The DGAC also notes that this change does not mean that cholesterol is completely harmless, but only that it is not considered harmful enough to limit, and that cholesterol remains a potential threat to cardiovascular health.” DGAC’s rationale for the above dietary recommendations on cholesterol is, first, that even if dietary cholesterol is controlled to <200 mg< span=""> per day (one egg yolk contains about 250 mg of cholesterol), LCL-C levels can only be reduced by 3-5%; second, while dietary cholesterol intake accounts for only 20-30% of total body cholesterol, endogenous liver Second, although dietary cholesterol intake accounts for only 20%-30% of total body cholesterol, endogenous cholesterol synthesis in the liver accounts for 70%-80%, and exogenous cholesterol intake has a significant negative feedback inhibitory effect on endogenous cholesterol synthesis, that is, increased exogenous cholesterol intake can negatively inhibit endogenous cholesterol synthesis; Third, after years of efforts, the U.S. National Cholesterol Education Program has been implemented relatively well, and the awareness, treatment and control rates of hypercholesterolemia are significantly Fourth, the United States has a strong capacity for independent innovation, with Pfizer and Mercer, the giants of the drug research and development industry, and the country can afford to take statins for all people in the short term, but in the long run, the social and economic benefits of improving the health of all people and reducing cardiovascular diseases are far beyond the money invested in drugs. Fifth, the “post-statin era” has obviously arrived, and the application of powerful lipid-lowering drugs such as ezetimibe and PCSK9 inhibitors on top of statin may need to consider the limit and inflection point of lipid-lowering treatment – a certain amount of cholesterol is, after all, necessary for us to complete our physiological functions; Sixth, to live is to be happy. With the above good lipid-regulating drugs available to all, it is important to get patients back to life – a balanced diet is part of a natural, happy life. How should we properly face the issue of cholesterol “lifting the ban” in the U.S. Dietary Guidelines?