There should be three consecutive goals for antiviral therapy: 1. A viral DNA load of less than 1,000 (500) copies/ml and normal liver function within 3 to 6 months is the first goal for achieving treatment. 2. The second goal requires E antigen seroconversion, and E antigen negative and E antibody emergence (i.e., major triplet to minor triplet). The time required to achieve this goal usually varies from 1 to 3 or 5 years, depending on the strength of the individual’s specific immunity. According to various international guidelines, the second goal is usually reached after 3 more years of medication before discontinuation can be considered. However, there will be a partial relapse after discontinuation; only the re-treatment remains effective.3. Of course, with long-term use, it is also possible to reach the third goal, namely the disappearance of surface antigens and the appearance of surface antibodies (anti-HBs). This is also the clinical cure that is currently proposed as an achievable and desirable goal. Therefore, antiviral therapy is a long-term process, usually three to five years or more before discontinuation can be considered, and requires discontinuation under medical supervision.