Multiple plasmapheresis is the presence of fluid in all cavities, including the thoracic, abdominal and pericardial cavities. The identification of polyplasmacytic disease requires a comprehensive analysis of a number of factors. Mainly through physical examination and imaging examination to clarify the site of effusion, and then puncture, remove a small amount of fluid, and its biochemical analysis, combined with the history of comprehensive judgment, you can clarify the cause of the disease. 1. Etiologic analysis, infection, cancer, autoimmune disease, congestive heart failure, cirrhosis, etc., can cause the production of multiple plasma lumen effusion. 2. To evaluate the condition of patients with polyplasmacytic effusion, firstly, the site of the effusion needs to be determined first, which requires physical examination and imaging tests, such as palpation of the affected area, CT, chest radiographs, color ultrasound, etc., to clarify the location, site, and border conditions. Puncture is then performed and biochemical tests including cell count and classification, glucose, adenosine deaminase (ADA) and cytologic analysis are performed. 3. A comprehensive evaluation of the results obtained from the aspiration fluid analysis, medical history, imaging studies and physical examination will lead to a definitive etiology and differential diagnosis. It is advisable to seek prompt medical attention for the development of polyplasmacytic disease or any discomfort in order to clarify the cause of the disease.