Hepatitis C patients often ask questions about Hepatitis C treatment, for example, they have applied interferon with little success and do not know what to do next. Here I would like to give my opinion for your reference. 1, experts agree that α-interferon is the only effective drug in the treatment of hepatitis C. Therefore, we hope that hepatitis C patients will not give up interferon treatment easily. We have encountered several patients with hepatitis C who had no response to interferon for 3 to 6 months, but the efficacy was obvious when it was applied for 9 months, and it has been applied for 12 months or even longer, and the ideal efficacy has been achieved. Some people have suggested that the application of interferon 6 months ineffective to stop, this is not necessarily accurate, stop using interferon what else can be used? Hepatitis C progresses slowly, unlike hepatitis B. The course of interferon treatment must be sufficient. Of course, the dosage can be increased from 3 million units/time to 5 million to 6 million units/time. 2.Compound interferon can be used instead. Compound interferon is a non-natural interferon obtained by applying genetic recombination technology to recombine various subtypes of interferon, which has at least 5 times greater anti-hepatitis C virus effect than the original α-interferon, and the adverse effects are mild to moderate, similar to other types of interferon. When patients with hepatitis C are ineffective with other types of interferon, they can be switched to complex interferon, which is administered by subcutaneous injection of 9 micrograms each time, three times a week, for a course of 6 to 12 months. This drug is available in the domestic market, Shanghai and other places have been used in the clinic, the effect is better. 3.Combination of drugs. The current recommended program is interferon combined with viral azole (ribavirin), can also be applied to interferon combined with thymidine (Tα1), the latter 1.6 mg per subcutaneous injection, applied 2 to 3 times a week. New research, the domestic Chinese medicine oxidized ginseng alkaloids injection in addition to anti-hepatitis B virus, there are anti-hepatitis C virus effect, some people apply to the clinic, each 200 mg intramuscular injection, 2 times a day, the efficacy is very good, not inferior to interferon. Interferon and interferon can be used jointly to treat hepatitis C. 4, Hepatitis C can not be cured, but also to analyze the reasons. Generally if hepatitis C is combined with cirrhosis, fatty liver, diabetes, heart disease, biliary tract infection, HIV infection, etc., it is difficult to treat. At this time for the comorbidities should also be appropriate treatment, otherwise will not receive satisfactory results. It is also found that many patients with refractory hepatitis C have high serum iron, and the liver cells contain much iron, which affects the therapeutic effect. Lactoferrin has been administered to hepatitis C patients to bind the excess iron and expel it from the body. Lactoferrin is a kind of transferrin, and at the same time has an immunomodulatory effect. 5, the problem of treatment indications is also important. Some hepatitis C virus-infected patients are not patients with therapeutic indications, or are not patients with indications for the application of interferon therapy. Patients with normal serum ALT (alanine aminotransferase, i.e., original GPT) levels are not indications for antiviral therapy; no fibrosis (FO stage) or mild hepatic fibrosis (F1 stage) does not necessarily require antiviral therapy. Patients with cirrhosis and hepatic decompensation are usually not given current antiviral therapy because it is ineffective. Experts suggest that hepatic fibrosis stages F2 and F3 of hepatitis C are the best indications for antiviral (interferon) therapy, and that antiviral therapy may be considered in the early stages of cirrhosis. Hepatitis C virus genotype is also related to antiviral therapy. Therefore, chronic hepatitis C patients should strive for liver biopsy and determination of hepatitis C virus genotype and viral load to provide a reliable basis for treatment. 6, the efficacy determination can not be completely based on ALT as the standard, mainly should be verified by hepatitis C virus ribonucleic acid (HCVRNA). If HCVRNA turns negative, it means that the effect of treatment is good; if the treatment is finished, HCVRNA is still negative, which is called “sustained response”, which is the most ideal. Some patients judge the efficacy of interferon by the positivity or negativity of anti-HCV, which is wrong, anti-HCV is an antibody, when HCVRNA is negative, anti-HCV can still be positive, and it can last for several years without disappearing. Therefore, hepatitis C patients must be tested for HCVRNA before and after treatment to accurately determine the efficacy of interferon, mo will be effective when.