1. General systemic treatment Those exposed to poisoning should quickly remove contaminated clothes and rinse the skin and mucous membranes repeatedly with large amounts of water. When inhaling poisonous gas, the sick child should be moved to an environment with clean air, oxygen should be administered if necessary, and tracheal intubation and mechanical ventilation should be performed for those with asphyxia. Accidental ingestion of pesticides should be promptly gastric lavage. Because organophosphorus pesticides (in addition to trichlorfon) are prone to decomposition in alkaline solution failure, it can be used 2%-4% sodium bicarbonate solution gastric lavage, but also physiological saline or water gastric lavage. As organophosphorus pesticide poisoning can prolong the gastric emptying time, so gastric lavage time is not limited, should be repeated, multiple times, thorough cleaning, until the lavage fluid tasteless. Before the end of gastric lavage, magnesium sulfate is instilled into the gastric tube to induce diarrhea, and oil-based laxatives are not used. Seriously ill children should be placed in the monitoring ward (room), with special guards, regular measurement of vital signs, pay attention to changes in the pupils. 2, special treatment (1) cholinergic neuroleptics: such as atropine can antagonize the muscarinic effect of acetylcholine, improve the body’s tolerance to acetylcholine, especially to release smooth muscle spasm, inhibit bronchial secretion, keep the airway open, prevent the occurrence of pulmonary edema and antagonistic effect on hypertension and arrhythmia, but not on the nicotine-like effect. When using atropine, pay attention to the changes in pupil size, skin color, heart rate and body temperature to prevent atropine overdose. When fever is present, physical cooling, oxygen administration and keeping the airway open should be used to prevent the occurrence of ventricular fibrillation. It is mainly effective for the poisoning caused by lego and malathion. (2) Cholinesterase resuscitator: there are dephosphoridine chloro dephosphoridine, double compound phosphorus, etc. They can seize the organic phosphorus bound to cholinesterase, restore the vitality of cholinesterase decomposition of acetylcholine, and have obvious effects on relieving nicotine-like effects and promoting the awakening of comatose children, and have synergistic effects with atropine. Mainly parathion endosulfan, methomyl and ethion poisoning have obvious effects. The above-mentioned antidotes should be used early, in sufficient quantity and repeatedly. In principle, two antidotes can be applied simultaneously to moderate and severe poisoning, and the dosage of atropine can be appropriately reduced at this time. 3. Other measures (1) Keep the respiratory tract unobstructed: clear respiratory secretions in time, intubate when there is respiratory failure, and administer oxygen under positive pressure. (2) Correct the disorders of water and electrolytes. (3) Master the infusion speed and volume of fluid: patients with pulmonary edema or cerebral edema should strictly master the infusion speed and volume of fluid. (4) Transfusion of fresh blood: Fresh blood can be transfused to those whose symptoms do not improve significantly during treatment, and supplement to improve the vitality of cholinesterase. (5) Adrenocorticotropic hormone: Adrenocorticotropic hormone can be given to patients with severe poisoning to inhibit antibody response to drugs, improve cerebral edema and pulmonary edema, and relieve bronchospasm and laryngeal edema. (6) Close observation: Close observation should be made for 24-48h to avoid recurrence of symptoms. 4. Treatment of comorbidities (1) Respiratory cardiac arrest: caused by a large amount of poisoning at one time or untimely resuscitation. Immediately after the occurrence, the respiratory tract should be cleared, artificial respiration or tracheal intubation, mechanical ventilation and effective cardiac compressions should be used to resuscitate the heart, lungs and brain as soon as possible, and atropine 0.1mg/kg should be used each time for 5-10min and repeated until resuscitation. (2) Acute respiratory failure: As a result of nicotine-like effects, resulting in respiratory paralysis to respiratory failure, mainly ventilation disorders, blood gas shows PaO2 <8.00kPa (60mmHg), PaCO2 >6.0kPa (45mmHg) can also be due to increased bronchial secretion, pulmonary edema leading to ARDS visible progressive inspiratory dyspnea with hypoxemia, at this time should be given early oxygen, Tracheal intubation, or tracheotomy and mechanical ventilation, positive end-expiratory pressure (PEEP) or high-frequency ventilation can be used, while dexamethasone 4-8mg intravenous push, followed by intravenous drip, once every 4-6 hours, for about 3 days. (3) Cardiac involvement: appropriate antiarrhythmic drugs are available. Ventricular fibrillation is promptly resuscitated by electricity, and overdrive cardiac pacing or isoproterenol can be used. (4) Atropine overdose: should be promptly discontinued (5) Gastrointestinal bleeding: early due to violent vomiting caused by esophageal mucosal tear syndrome; or due to gastric lavage injury, toxic corrosion of the gastric mucosa resulting in erosion or ulcer bleeding; late due to hypoxia, high-dose adrenocorticotropic hormone application of diffuse hemorrhagic gastritis, available ice water or saline with norepinephrine orally or instillation, shock should be expanded (6) rebound and organophosphorus Toxic effects of solvents: The most common is lego poisoning, that is, 3-10 days after the successful rescue and sudden manifestation of acute poisoning symptoms of mental changes pulmonary edema and respiratory failure. Some show cardiac arrhythmia, and the patient can die quickly. To prevent the occurrence of rebound, first of all, the stomach should be thoroughly lavaged, and the amount of atropine antidote should be sufficient and the duration should be long.