Headache is a symptom that can be caused by a variety of clinical diseases, and the pain relief methods vary from disease to disease. If it is caused by hypertension, the main treatment is to lower blood pressure, commonly used drugs are levoclodipine, amlodipine besylate, irbesartan, also can apply enalapril and so on. If the patient’s blood pressure is severely elevated, you can also apply nifedipine in small doses. Nifedipine is a short-acting blood pressure-lowering drug that works quickly and has a short maintenance time, and is suitable for temporary antihypertensive treatment for patients in the acute phase. In addition, if the headache is caused by increased intracranial pressure, the main treatment is to lower the cranial pressure, which is mainly seen clinically in cerebrovascular diseases, including cerebral infarction and cerebral hemorrhage. It may also be caused by infectious diseases of the central system, and commonly used cranial-lowering drugs include mannitol and glycerol fructose. If the patient has cranial trauma that can also cause headache, pain medications such as ibuprofen and indomethacin can be applied for treatment, along with aggressive treatment of the trauma. In case of primary headache disorders, such as tension headache and cluster headache, symptomatic analgesic treatment is mainly carried out, and commonly used drugs include acetaminophen, ibuprofen, indomethacin, and also ergotamine caffeine, zolmitriptan and sumatriptan, etc.