Headache is common in patients with cerebral hemorrhage and subarachnoid hemorrhage, and it is also a common symptom of cerebral infarction, but it is often masked by other symptoms or ignored by everyone in clinical practice. Cerebral infarction caused by cerebral artery entrapment and venous sinus thrombosis is usually accompanied by headache, and not only that, about 25% – 29% of patients with cerebral infarction have headache symptoms. The mechanism of headache caused by cerebral infarction is not clear, and may include the following aspects: 1. The distribution of blood vessels at the base of the brain is similar to that of the trigeminal nerve, and the stimulation of trigeminal nociceptive fibers after vascular injury causes headache; 2. The occlusion of intracranial and extracranial blood vessels is followed by vasodilation, the opening of collateral circulation, and changes in vascular perfusion; 3. The release of vasoactive substances such as prostaglandins, norepinephrine, and NO, etc. cause headache; 4. Intracranial pressure changes after cerebral infarction cause intracranial pain-sensitive structures to be stretched or deformed causing headache. The headache caused by cerebral infarction has its own clinical characteristics. Headache mostly occurs in the posterior circulation, cerebral thrombosis more than cerebral embolism, cortical infarction more than deep penetrating branch, and venous infarction more than artery. Headaches are more common in patients under 40 years of age, more common in women than men, more common in patients with previous migraine, more common in left hemisphere infarcts than right, and more likely to occur in patients with blood pressure below 120/70 mmHg. The nature of headache associated with cerebral infarction is varied, and it can manifest as tension headache, migraine, throbbing headache and diffuse headache, etc. The degree of which can be mild or severe. Nausea, vomiting, photophobia and phonophobia are common concomitant symptoms. The pain may worsen with changes in head position. Headaches associated with cerebral infarction usually last up to 25 hours. There is no significant correlation between the severity of headache and the size of the infarct, and headache does not affect the prognosis of infarction. As headache is a common symptom of cerebral infarction, we should understand and pay attention to the headache associated with cerebral infarction, look for possible causes, such as cerebral artery entrapment and venous sinus thrombosis, and improve the prognosis of patients with early treatment.