The need for treatment of syphilis a negative and a positive depends on the specific situation and cannot be unified. A negative syphilis generally refers to the results of syphilis serological testing of syphilis-specific antibodies and syphilis non-specific antibodies, which can be divided into the following cases: 1, syphilis-specific antibodies positive, syphilis non-specific antibodies negative: at this time there are two possibilities, one for syphilis previous infection has been cured, at this time the syphilis-specific antibodies due to previous infection is difficult to turn negative, most people will continue to This situation does not require treatment. Another situation is the very early stage of syphilis infection, because syphilis non-specific antibodies are produced later than syphilis-specific antibodies, the concentration of reactive elements contained in the body at this time is low, not detected and negative, but in fact there has been syphilis infection, then you need to recheck the titer after 4 weeks, and combined with clinical symptoms, epidemiological history, etc., once the syphilis infection is diagnosed should be treated immediately; 2, syphilis-specific antibodies Negative, positive syphilis non-specific antibodies: one is non-syphilis infection, but there are other cross-antigens in the body causing positive syphilis non-specific antibodies, such as rheumatoid arthritis, systemic lupus erythematosus, acute hepatitis, leprosy, etc., or other spirochete infections in the body, at this time there is no need for anti-syphilis treatment, but treatment for other diseases is required. Another situation is the syphilis-specific antibody test is false negative, the actual syphilis infection, although this situation is rare, but limited to the limitations of the test, can be replaced by another test method or reagents for simultaneous verification, for such cases also need clinical treatment.