In the outpatient work often encounter syphilis patients, some are first-time diagnosis, some are referred from outside the hospital. Most of the patients are nervous, anxious, and anxious for the doctor to cure immediately, this mood doctor understand. This is mainly caused by the patient’s lack of understanding of the etiology, treatment and prevention of the disease. I combine many years of clinical work, to talk about their own experience. The source of this disease is syphilis spirochete, the transmission is: sexual transmission, mother-to-child transmission, blood transmission of the three major ways, of course, indirect infection is also not uncommon in clinical. Such as contaminated baths, hands contaminated masturbation, and syphilis sexual partners (do not know each other sick) violent kissing, sharing toothbrushes, etc.. Our doctor’s duty is: “prevention and control, prevention first” so the doctor should first tell the patient not to be nervous, to cooperate with the doctor’s treatment, sexual partners should come to the clinic at the same time. In the future, we should pay attention to: 1, avoid unclean sexual contact. 2, exercise, increase immunity. 3, wash your hands after activities in public places. 4.Bring condoms when necessary. Treatment of syphilis: It is not complicated, but the review period is long. Penicillin is the treatment of choice. Currently, the following are commonly used: double-acting penicillin, 800,000 units, one per day, 15 days of continuous injection; benzathine penicillin 1.2 million units, 2.4 million units per week, 3 – 4 weeks of continuous injection. The treatment of syphilis is not complicated, but the review cycle is long, do not rush, three months after treatment to review, the first year four times; the second year two times (every six months); the end of the third year another test. Until the RPR turns negative. In some patients, the RPR is negative in one or two years, so the test is no longer needed. Some patients, just a week after the injection, asked for laboratory tests, some patients after the first test RPR ratio is not fast decline, then asked to inject penicillin again, which is unnecessary. 2.The skin test should be done before injecting penicillin. 3.After penicillin injection, some patients have fever, which is a normal phenomenon, clinically called “Jihai reaction”, if the fever does not exceed 38.5c, drink more water and take appropriate antipyretic drugs. 4, such as early pregnancy found to have syphilis, to go to the obstetrics and gynecology department to study the issue of the child to stay. 5.Some patients ask: Is it contraindicated to have this disease on diet? When there is an ulcer on the lower body, you should not drink alcohol or eat chili peppers, but there are no other taboos. 6.Some patients ask: When can I have sex? If there are ulcers on the lower body, it is better not to have sex, if necessary, wear condoms, after treatment RPR 1:8 or less can contact, but it is best to wear condoms.