Some depression can be self-healed, especially mild depression patients can get self-healing through self-adjustment and self-psychological suggestion, such as: 1. Mild depression can be self-adjusted such as moderate exercise to stimulate the secretion of endorphins, which plays an anti-anxiety and anti-depressant role. Turning attention to activities of interest can stimulate the patient’s sense of pleasure and control, so that the patient’s motivation is increased and the patient’s emotional state is improved.2. Patients with moderate and severe depression need medication to heal, and not treating or postponing treatment is detrimental to the development of the disease. Moderate and severe depression patients mainly through the application of antidepressant drugs, more commonly used 5-hydroxytryptamine reuptake inhibitors, such as paroxetine, sertraline, fluoxetine, venlafaxine, etc. have good results, but we should pay attention to the full amount, the full course of treatment, the system standardized treatment.