Thrombocytosis is prone to the formation of thrombosis and bleeding, so active treatment should be given: 1, bone marrow inhibitors, commonly used is hydroxyurea, which belongs to chemotherapy drugs, can inhibit bone marrow hematopoiesis, usually start with a larger amount, 2-4g/d, after 3-4 days reduced to 1g/d. Other commonly used drugs are leucovorin, nitrogen mustard phenylbutyrate, cyclophosphamide, mafran, these are also effective. But usually the most clinically used hydroxyurea, side effects are relatively small, platelet decline or remission can stop the drug. If there is a relapse, you can continue to use the drug.2. Radionuclide phosphor therapy, which can easily induce leukemia, is generally not recommended.3. Platelet detachment, which can reduce the platelet count and improve bleeding faster, is usually used for gastrointestinal bleeding, pregnancy and delivery, and elective pre-surgery.4. Interferon is also effective.5. Dipyridamole, aspirin, and anti-inflammatory and painkiller therapy.6. If there is thrombosis, you can use heparin or bicoumarin. Heparin or bicoumarin-based anticoagulants can be used. Platelet increase cut spleen is absolutely contraindicated.