The pain is usually heavy in the late stage of myeloma, but if there is a sudden inability to feel pain, it may be a sign that the disease has progressed to the end stage, and there may be nerve paralysis, a state of malignant fluid in patients with advanced myeloma, and severe malnutrition, which may occur in a situation where the disease does not feel very painful, but the disease has spread widely and metastasized. There is no too good treatment for this condition. If there is no pain, there can be no need to use pain medication, but symptomatic treatment such as blood transfusion, blood supplementation and nutritional support can be applied, and there is no other good way for advanced myeloma. If the patient’s physical condition can tolerate it, he can consider doing adjuvant chemotherapy, targeted drugs and other treatment modalities again to see if he can control the development of the disease and prolong the survival treatment. Also look at the side of treatment, strengthen the company and give more care to the patient.