Positive immunofixation electrophoresis does not necessarily mean myeloma. The diagnostic criteria for multiple myeloma mainly refer to the proportion of plasma cells in the bone marrow ≥10%, plus the presence of four major clinical manifestations, including bone destruction, anemia, renal impairment, and hypercalcemia. Positive immunofixation electrophoresis only indicates that the plasma cells are clonal, but clonal plasma cells can be asymptomatic, and the diagnosis of multiple myeloma cannot be made in the absence of symptoms. Other B-cell diseases such as lymphoma can also show positive immunofixation electrophoresis, so positive immunofixation electrophoresis does not necessarily mean myeloma. Myeloma has its own unique diagnostic criteria, mainly the percentage of plasma cells in the bone marrow ≥10%, plus the four major clinical manifestations caused by elevated immunoglobulin in myeloma to determine.