In advanced myeloma fever, it is important to first clarify exactly what the cause of the fever is, whether it is an infection or the myeloma itself. It can be serious if there is a combination of infection, especially if there is a combination of bacterial infection. Because myeloma patients themselves have a low immune system, they are prone to secondary infections. Once an infection occurs, especially in the lungs, it needs to be managed aggressively with strong antibiotics to control the infection. If the infection is once controlled, the patient may survive progression-free or as long as possible. Myeloma itself can also cause low- or moderate-grade fever, so it is important to make a good differential diagnosis. Pulmonary infections have obvious symptoms of cough and sputum, and inflammation will show up on CT of the lungs. Fever due to myeloma itself is mostly low to moderate fever with no symptoms of chills or chills.