More than 50% of patients with gallbladder stones have no clinical symptoms, and only about 30% have severe clinical symptoms, such as abdominal pain (epigastric or right upper abdominal paroxysmal spasmodic pain with progressive aggravation, often radiating to the back of the right shoulder), gastrointestinal reactions (nausea, vomiting, abdominal pain not relieved after vomiting), fever and chills (inflammatory reaction), jaundice (mostly transient), etc. The incidence of gallbladder stones is higher in Beijing, Shanghai, Northwest and North China. Do I have to have my gallbladder removed if I have gallbladder stones? Not necessarily! 1. Long-term asymptomatic gallbladder stones: surgery is not required for the general population. It is recommended to adjust the dietary structure and lifestyle. 6-12 months to review, if the stones increase in size, increase, or appear similar to stomach disease, indigestion symptoms, further examination is required. Patients with asymptomatic gallbladder stones in combination with diabetes mellitus and liver cirrhosis may consider surgery. 2. There are several ways to deal with gallbladder stones with clinical symptoms as follows: 1) Conservative treatment: preferred in acute attacks or those with contraindications to surgery. Conservative treatment is mainly bed rest, fasting, intravenous rehydration (correction of water, electrolytes, acid-base disorders), gastrointestinal decompression, sedation and pain relief, application of broad-spectrum antibiotics, parenteral nutrition, etc. (2) Lithotripsy and bile preservation: oral lithotripsy drugs and minimally invasive lithotripsy surgery are available, but the recurrence rate is high. Minimally invasive lithotripsy requires asymptomatic gallbladder stones, good gallbladder contraction, insignificant gallbladder inflammation, thin gallbladder wall, no combined gallbladder polyps, and desirable stone location, etc. There are certain restrictions. (3) Cholecystectomy: the most effective and reliable radical treatment for gallbladder stones at present. Laparoscopic cholecystectomy has become the current “gold standard” of gallbladder surgery. Large stones, gallbladder polyps, gallbladder wall thickening or calcification, combined cirrhosis or diabetes, cardiopulmonary dysfunction, children or people with inconvenient access to medical care, and people with gallbladder stones for more than 10 years can be considered for gallbladder removal. The treatment of gallbladder stones needs to be combined with individual health conditions, and there are strict indications for both conservative and surgical treatment. Once the diagnosis of gallbladder stones is confirmed, it is necessary to arrange the diet and living in a reasonable way, correct the bad habits that may lead to gallbladder stones, and not to aggravate the development of gallbladder stones as much as possible. Do not be afraid of gallbladder stones, seek medical advice and choose the right treatment according to your doctor’s recommendations.