The clinical manifestations of syphilis usually do not have obvious gender differences, and there are only some male-specific parts of the genital system that are damaged. The symptoms of syphilis are usually divided into stage 1, stage 2 and stage 3 syphilis, and the manifestations are not limited to 5 types, which can be divided into the following according to different stages: 1. Stage 1 syphilis: 1. Hard chancre: often manifested as small red spots, hard nodes and ulcers on the external genitalia, not painful or itchy, can be single or multiple, mostly seen on the penis, glans, foreskin and tethered belt in men, and can heal spontaneously in 1-2 weeks; 2. Lymph node enlargement: 1-2 weeks after the appearance of hard chancre, the lymph nodes in the groin or the affected area may appear significantly enlarged, but there is no pain. Syphilis rash: generalized red or reddish-brown rash, papules and plaques, ulcers and pustules on skin mucous membrane such as mouth, throat and genitalia, flat warts and condyloma acuminata around the anus, etc., which are not painful or itchy and can generally subside on their own in 2-3 months; 2. Systemic symptoms: muscle pain, joint swelling, fever, sore throat, patchy hair loss, vision Decline, nerve damage, such as headache, vomiting, sleepiness, slow reaction, etc. Stage III syphilis: 1. Skin and mucous membrane damage: nodular syphilis rash may appear, manifested by clusters of copper-red nodules on the head, face and back of the shoulders, and syphilitic dendritic swelling, manifested by 2-10 cm sharp-edged horseshoe ulcers, producing sticky dendritic secretions, as well as damage to the skin and mucous membranes of the mouth and eyes, resulting in difficulty in pronunciation and swallowing, visual impairment and even blindness; 2. Bone Syphilis: the more commonly affected areas are the head and facial bones and tibia, which can produce diseases such as periostitis, osteomyelitis, and arthritic osteoarthritis, often presenting symptoms such as bone pain, pathological fracture, bone perforation, joint deformity, and often severe bone pain at night; 3, cardiovascular syphilis: it can cause syphilitic simple aortitis, manifesting as discomfort or pain in the middle of the chest, which can be accompanied by breathing difficulties, and syphilitic aortic valve Inadequate closure of the aortic valve, after the doctor’s auscultation found a murmur in the heart as well as a sudden rise and fall of the pulse. Syphilitic coronary artery stenosis or obstruction can cause pain in the middle of the chest, and the attack lasts for a long time, and the symptoms are usually aggravated at night. The diagnosis needs to be confirmed by cerebrospinal fluid examination. Patients with syphilis in the third stage have more pronounced neurological symptoms, including headache, cognitive and memory loss, impaired and lost language skills, abnormal mental behavior, hemiplegia, and limb incoordination. The neurological damage caused by syphilis is usually irreversible and needs to be diagnosed and treated in a timely manner to avoid permanent damage to the patient. If symptoms of syphilis are found, it is recommended to go to the hospital for relevant examinations in a timely manner to confirm the diagnosis and treat the disease as soon as possible. If early detection and early treatment can be achieved in stage I or II, patients may not progress to stage III. In daily life, attention should be paid to keeping the affected area clean and hygienic, and sexual life should be avoided during the treatment period.